Title:Of monkeys and men: a metabolomic analysis of static and dynamic urinary metabolic phenotypes in two speciesOf monkeys and men: a metabolomic analysis of static and dynamic urinary metabolic phenotypes in two species
, P. Verbruggen, ,
J. van der Greef,
, A.K. Smilde
Abstract:BACKGROUND: Metabolomics has attracted the interest of the medical community for its potential in predicting early derangements from a healthy to a diseased metabolic phenotype. One key issue is the diversity observed in metabolic profiles of different healthy individuals, commonly attributed to the variation of intrinsic (such as (epi)genetic variation, gut microbiota, etc.) and extrinsic factors (such as dietary habits, life-style and environmental conditions). Understanding the relative contributions of these factors is essential to establish the robustness of the healthy individual metabolic phenotype.